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Mutant strains of different organisms lacking the housekeeping enzyme could be complemented by overexpression of a paralog, revealing a conserved function

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This mechanistic link explains why oxidative stress can amplify SASP-mediated tissue damage, creating a self-reinforcing cycle of inflammation and cellular dysfunction.18 Senolytics reduce SASP not only by eliminating the senescent cells that produce high ROS but also by disrupting pro-survival signaling pathways that sustain SASP activity

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